91糖心vlog传媒

l 教育和研究简历

1. 1998.6 - 迄今：91糖心vlog传媒，教授（1999-2009期间担任生物系主任/院长；2008-2017年期间担任91糖心vlog传媒副校长）

2. 1996.2 - 1998.6：中科院遗传所“负压室”804组 (现: 中科院遗传与发育所“植物基因组国家重点实验室”)，博士后（植物分子遗传）

3. 1992.9-1995.12：东北师大“细胞与遗传研究所”博士（植物遗传）

4. 1988.9 - 1992.7：南充师范学院生物系，讲师、副教授

5. 1985.9 – 1988.7：东北师大生物系，硕士（植物细胞工程）

6. 1982.2 - 1985.7：南充师范学院生物系，助教

7. 1978.2 - 1982.2：南充师范学院（现: 西华师范大学）生物系，学士

中国植物学会常务理事（2003-2023），北京市细胞生物学学会副理事长（2009-2017），国家自然科学基金委学科评议组成员（2006-2010连任两届），教育部高等学校生物科学与工程生物学基础课程教学指导分委员会委员（2006-2010）、教育部基础教育课程教材专家工作委员会委员（2014-2017）、教育部第叁届学科发展与专业设置专家委员会委员（2010-2014）、教育部大学生物学课程教学指导委员会副主任委员（2013-2017），《生物学通报》常务编委（2007-），《植物学报》编委（2007-），中科院植物研究所北方植物资源重点实验室学术委员会委员（2013-），中科院植物研究所分子生理学重点实验室学术委员会委员（2016-）。

主持国家重大专项、国家重大基础研究（973）和863课题、国家杰出青年科学基金（B类）、国家自然科学基金重点项目/重大研究计划/面上项目、北京市自然科学重点项目等19项。

领导的研究小组在植物逆境应答领域长期聚焦于：1、植物适应环境巨变（如，从水生到陆生、青藏高原隆起、全球气候变暖等）的遗传机制，对孓遗植物藻苔（Takakia lepidozioides）在青藏高原隆起而致极端环境下的适应机制、影响光合真核细胞起源和植物祖先登陆的重大遗传事件、植物产生二氧化碳和甲烷的分子调控机制等，进行了开创性研究。2、NO（一氧化氮）-ABA信号与植物逆境应答。在相关研究领域取得了系列学术成果，本团队为主体并以责任作者身份在Cell, Cell Research, Molecular Plant, PNAS, NAR, Plant Physiology, Sci China C Life Sci, Chinese Science Bulletin等，以及Science（第一作者）, Nature, Nature Plants, Nature Communication（合作者）等学术期刊发表研究论文60余篇。

主编高等师范院校新世纪教材《细胞生物学》（2009年，科学出版社）。2005、2009年2次获北京市教育教学成果(高等教育)奖二等奖（排名第一），2005年获“北京市先进工作者(劳模)”称号，2006年被评为北京市高校创新拔尖人才，2007年获北京市高等学校教学名师奖，2016年获国务院“政府特殊津贴”，2021年获首届全国教材建设奖(一等奖)，2023获中国植物学会九十周年突出贡献奖、北京自然科学二等奖(排名第叁)。

1. 西藏科技厅重点项目，项目号XZ202301ZY0009N，西藏濒危珍稀植物藻苔种质资源保护及抗紫外活性物开发（2023.03.01至2025.12.31）

2. 国家自然科学基金面上项目，项目号31970658，小立碗藓转录因子PpTF66调控离子通道PpSOT1在盐胁迫应答中的作用机制（2020.01-2023.12）

3. 国家自然科学基金重大研究计划，项目号91631109，银叶真藓适应极端环境的基因组特征及关键基因的作用机制（2017.01-2019.12）

4. 国家自然科学基金重点项目，项目号31530006，拟南芥一氧化氮合酶(NOS)解析及NO信号途径对(水分)胁迫的应答（2016.01-2020.12）

5. 国家自然科学基金面上项目，项目号31470357，小立碗藓水分胁迫应答中通过miRNA66调控ABA平衡的分子机制（2015.01-2018.12）

6. 国家“转基因生物新品种培育科技重大专项”， 项目号2014ZX0800923B，苔藓等抗干旱主效基因或元件的克隆与功能分析（2014.01-2016.12）

7. 国家重大科学研究计划，项目号2013CB967301，微环境调控生长点干细胞维持与分化的信号网络（2013-2017）

8. 国家“转基因生物新品种培育科技重大专项”，项目号2009ZX08009-058B，极端生境藓类抗逆 (干旱等)“主效”基因/调控元件分离及功能验证（2009.06.01-2010.12.31）

9. 国家重大科学研究计划，项目号2007CB948201，植物生长点干细胞的维持机制（2007-2011）

10. 国家高技术研究发展计划（863计划），项目号2007AA021405，特殊低等植物抗逆基因的开发利用（2007-2010）

11. 北京市自然科学基金重点项目(B类)，项目号Z200610028017，小立碗藓胁迫应答蛋白组分析及抗逆基因分离（2005-2008）

12. 国家自然科学基金面上项目，项目号30470879，叶绿体分裂环定位相关基因(minC或类似物)克隆及功能解析（2005.01 - 2007.12）

13. 北京市自然科学基金，项目号5052005，拟南芥minC基因克隆及对FtsZ等蛋白定位的影响（2005-2007）

14. 国家自然科学基金杰出青年基金(B类项目—海外青年学者合作研究基金)，项目号30328003，高等植物中Ca2+与NO相互作用分子调控机理（2004-2006）

15. 北京市自然科学基金重点项目，项目号5021001，极端生境藓类代表种的功能基因组分析及抗逆基因克隆（2002-2005）

16. 国家自然科学基金面上项目，项目号39970356，FtsZ基因的cDNA克隆以及在叶绿体分裂过程中的作用机制（2000.01-2002.12）

17. 北京市自然科学基金，项目号5995003，FTSZ基因控制叶绿体分裂的作用机理（2000-2002）

1. Hu R?, Li X?, Hu Y, Zhang R, Lv Q, Zhang M, Sheng X, Zhao F, Chen Z, Ding Y, Yuan H, Wu X, Xing S, Yan X, Bao F, Wan P, Xiao L, Wang X, Xiao W, Decker EL, van Gessel N, Renault H, Wiedemann G, Horst NA, Haas FB, Wilhelmsson PKI, Ullrich KK, Neumann E, Lv B, Liang C, Du H, Lu H, Gao Q, Cheng Z, You H, Xin P, Chu J, Huang CH, Liu Y, Dong S, Zhang L, Chen F, Deng L, Duan F, Zhao W, Li K, Li Z, Li X, Cui H, Zhang YE, Ma C, Zhu R, Jia Y, Wang M, Hasebe M, Fu J, Goffinet B, Ma H, Rensing SA, Reski R*, He Y* (2023). Adaptive evolution of the enigmatic Takakia now facing climate change in Tibet. Cell, 186(17): 3558-3576

2. Zhu W, He Y*(2023). α-Ketoglutarate dehydrogenase (KGDH): A new balancer between energy metabolism and gene expression in plants. J Integr Plant Biol., 65(8): 1843-1845

3. Zhang S, Tang K, Yan Q, Li X, Shen L, Wang W, He YK, Kuang T, Han G, Shen JR, Zhang X (2023). Structural insights into a unique PSI-LHCI-LHCII-Lhcb9 supercomplex from moss Physcomitrium patens. Nat Plants, 9(5): 832-846

4. Lv Q, Han S, Wang L, Xia J, Li P, Hu R, Wang J, Gao L, Chen Y, Wang Y, Du J, Bao F, Hu Y, Xu X, Xiao W*, He Y*(2022). TEB/POLQ plays dual roles in protecting Arabidopsis from NO-induced DNA damage. Nucleic Acids Res, 50(12): 6820-6836

5. Wang Y, Wang J*, Lv Q, He YK* (2022). ADH2/GSNOR1 is a key player in limiting genotoxic damage mediated by formaldehyde and UV-B in Arabidopsis. Plant, Cell & Environment, 45: 378-391

6. Wang X, Feng C, Tian L, Hou C, Tian W, Hu B, Zhang Q, Ren Z, Niu Q, Song J, Kong D, Liu L, He Y, Ma L, Chu C, Luan S, Li L* (2021). A transceptor-channel complex couples nitrate sensing to calcium signaling in Arabidopsis. Mol Plant, 14(5): 774-786

7. Zhang Y, Zhang X, Cui H, Ma X, Hu G, Wei J, He Y, Hu Y* (2021). Residue 49 of AtMinD1 Plays a Key Role in the Guidance of Chloroplast Division by Regulating the ARC6-AtMinD1 Interaction. Frontiers in Plant Science. doi: 10. 3389/ fpls.2021.752790

8. Niu GQ, Guo Q, Wang J, Zhao S, He YK*, Liu L*(2020). Structural basis for plant lutein biosynthesis from alpha-carotene. Proc Natl Acad Sci USA, 117(25): 14150-14157

9. Chen L, Bao F, Tang S, Zuo E, Lv Q, Zhang D, Hu Y, Wang X*, He Y* (2019). PpAKR1A, a Novel Aldo-Keto Reductase from Physcomitrella Patens, Plays a Positive Role in Salt Stress. IJMS, 20, 5723; doi:10.3390/ijms20225723

10. Xiao L, Yobi A, Koster KL, He Y, Oliver MJ (2018). Desiccation tolerance in Physcomitrella patens: Rate of dehydration and the involvement of endogenous abscisic acid (ABA). Plant Cell Environ. 41(1): 275-284

11. Zhao M, Li Q, Chen Z, Lv Q, Bao F, Wang X*, He Y*(2018). . International Journal of Molecular Sciences, 19(9): 2728;

12. Wang L, Kong D*, Lv Q, Niu GQ, Han T, Zhao X, Meng S, Cheng Q, Guo S, Du J, Wu Z, Wang J, Bao F, Hu Y, Pan X, Xia J, Yuan D, Han L, Lian T, Zhang C, Wang H, He XJ, He YK (2017). Tetrahydrofolate modulates Floral Transition through Epigenetic Silencing. Plant Physiol. 174: 1274-1284

13. Niu G, Zhao S, Wang L, Dong W, Liu L*, He Y* (2017). Structure of the Arabidopsis thaliana NADPH-cytochrome P450 reductase 2 (ATR2) provides insight into its function. The FEBS Journal, doi:10.1111/febs.14017

14. Li Q, Zhang X, Lv Q, Zhu D, Qiu T, Xu Y, Bao F, He Y*, Hu Y* (2017). Physcomitrella Patens Dehydrins (PpDHNA and PpDHNC) Confer Salinity and Drought Tolerance to Transgenic Arabidopsis Plants. Frontiers in Plant Science, doi: 10.3389/fpls.2017.01316

15. Wang J, Wang Y, Lv Q, Wang L, Du J, Bao F, He YK* (2017) Nitric oxide modifies root growth by S-nitrosylation of plastidial glyceraldehyde-3-phosphate dehydrogenase. 10.1016/j.bbrc.2017.05.012

16. Lv Q, Wang L, Wang JZ, Li P, Chen YL, Du J, He YK*, Bao F* (2017). SHB1/HY1 Alleviates Excess Boron Stress by Increasing BOR4 Expression Level and Maintaining Boron Homeostasis in Arabidopsis Roots. Frontiers in Plant Science, doi: 10.3389/fpls.2017.00790

17. Wang X*, Chen L, Yang A, Bu C, He Y* (2017). Quantitative Proteomics Analysis of Developmental Reprogramming in Protoplasts of the Moss Physcomitrella patens. Plant Cell Physiol, 58(5): 946-961

18. Zhang ZW, Luo S, Zhang GC, Feng LY, Zheng C, Zhou YH, Du JB, Yuan M, Chen YE, Wang CQ, Liu WJ, Xu XC, Hu Y, Bai SL, Kong DD, Yuan S*, He YK (2017). Nitric oxide induces monosaccharide accumulation through enzyme S-nitrosylation. Plant Cell Environ, 40(9): 1834-1848

19. Zhang RJ, Peng WJ, Liu WZ, Li XD* and He YK* (2016). From spore germination to gametophyte development: the culture, propagation and anatomical protonemal structure of Takakia lepidozioides (Bryophyta) in Tibet plateau. Cryptogamie, Bryologie, 37 (4): 383-397

20. Hu R, Xiao L, Bao F, Li X, He Y* (2016). Dehydration- responsive features of Atrichum undulatum. Journal of Plant Research, 129: 945-954

21. Du J, Wang L, Zhang XC, Xiao X, Wang F, Lin PL, Bao F, Hu Y and He Y* (2016). . , 59(2): 182-193

22. Yuan S*, Zhang ZW, Zheng C, Zhao ZY, Wang Y, Feng LY, Niu G, Wang CQ, Wang JH, Feng H, Xu F, Bao F, Hu Y, Cao Y, Ma L, Wang H, Kong DD, Xiao W, Lin HH, He Y* (2016). Arabidopsis cryptochrome 1 functions in nitrogen regulation of flowering. Proc Natl Acad Sci USA, 113(27): 7661-7666

23. Zhou YH, Zhang ZW, Zheng C, Yuan S, He Y (2016). Nitrogen regulates CRY1 phosphorylation and circadian clock input pathways. Plant Signal Behav, 11(9): e1219830. doi: 10.1080/15592324.2016.1219830

24. Xia J, Wang X, Perroud PF, He Y, Quatrano R, Zhang W* (2016). Endogenous Small-Noncoding RNAs and Potential Functions in Desiccation Tolerance in Physcomitrella Patens. Sci Rep, 2016 Jul 22; 6:30118. doi: 10.1038/srep30118

25. Xiao L, Yang G, Zhang L, Yang X, Zhao S, Ji Z, Zhou Q, Hu M, Wang Y, Chen M, Xu Y, Jin H, Xiao X, Hu G, Bao F, Hu Y, Wan P, Li L, Deng X, Kuang T, Xiang C, Zhu JK*, Oliver MJ*, He Y* (2015). The resurrection genome of Boea hygrometrica: A blueprint for survival of dehydration. Proc Natl Acad Sci USA, 112(18): 5833-5837

26. Zhang F, Han M, Lv Q, Bao F, He Y* (2015). Identification and expression profile analysis of NUCLEAR FACTOR-Y families in Physcomitrella patens. Front. Plant Sci. 6, 642. http://doi.org/10.3389/ fpls.2015.00642

27. Tian W, Hou C, Ren Z, Pan Y, Jia J, Zhang H, Bai F, Zhang P, Zhu H, He Y, Luo S*, Li L*, Luan S* (2015). A molecular pathway for CO2 response in Arabidopsis guard cells. Nature communications, 6: 6057, doi: 10.1038/ncomms7057

28. Qin X, Wang W, Chang L, Chen J, Wang P, Zhang J, He Y, Kuang T, Shen JR* (2015). Isolation and characterization of a PSI-LHCI super-complex and its sub-complexes from a siphonaceous marine green alga, Bryopsis Corticulans. Photosynth Res, 123(1):61-76

29. Xia J, Kong D*, Xue S, Tian W, Li N, Bao F, Hu Y, Du J, Wang Y, Pan X, Wang L, Zhang X, Niu G, Feng X, Li L, He Y* (2014). Nitric oxide negatively regulates AKT1-mediated potassium uptake through modulating vitamin B6 homeostasis in Arabidopsis. Proc Natl Acad Sci USA, 111: 16196-16201

30. Yuan F*, Yang H, Xue Y, Kong D, Ye R, Li C, Zhang J, Theprungsirikul L, Shrift T, Krichilsky B, Johnson DM, Swift GB, He Y, Siedow JN, Pei Z* (2014). OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis. Nature, 514: 367-371

31. Wang X, Zhou S, Chen L, Quatrano RS, He Y* (2014). Phospho-proteomic analysis of developmental reprogramming in the moss Physcomitrella patens. J Proteomics, 108: 284-294

32. Wang X, Qi M, Li J, Ji Z, Hu Y, Bao F, Mahalingam R, He Y* (2014). The phospho-proteome in regenerating protoplasts from Physcomitrella patens protonemata shows changes paralleling postembryonic development in higher plants. J Exp Bot, 65 (8): 2093-2106

33. Du J, Li M, Kong D, Wang L, Lv Q, Wang J, Bao F, Gong Q, Xia J, He Y*(2014). Nitric oxide induces cotyledon senescence involving co-operation of the NES1/MAD1 and EIN2-associated ORE1 signalling pathways in Arabidopsis. J Exp Bot, 65(14): 4051-4063

34. Bai S*, Yao T, Li M, Guo X, Zhang Y, Zhu S, He Y* (2014). PIF3 is involved in the primary root growth inhibition of Arabidopsis induced by nitric oxide in the light. Mol Plant, 7: 616-625

35. Liu WZ, Kong DD, Gu XX, Gao HB, Wang JZ, Xia M, Gao Q, Tian LL, Xu ZH, Bao F, Hu Y, Ye NS, Pei ZM, He YK* (2013). Cytokinins can act as suppressors of nitric oxide in Arabidopsis. Proc Natl Acad Sci USA, 110: 1548-1553

36. Xiao L, Zhang L, Yang G, Zhu H, He Y* (2012). Transcriptome of protoplasts reprogrammed into stem cells in Physcomitrella patens. PLoS ONE, 7: e35961

37. Bai S*, Li M, Yao T, Wang H, Zhang Y, Xiao L, Wang J, Zhang Z, Hu Y, Liu W, He Y* (2012). Nitric oxide restrain root growth by DNA damage induced cell cycle arrest in Arabidopsis thaliana. Nitric Oxide - Biology and Chemistry, 26: 54-6

38. Cui S*, Hu J, Guo S, Wang J, Cheng Y, Dang X, Wu L, He Y* (2012). Proteome analysis of Physcomitrella patens exposed to progressive dehydration and rehydration. Journal of Experimental Botany, 63: 711-726

39. Wang H*, Jin S, Chen X, Gen X, He Y (2012). Target deletion of the AAA ATPase PpCDC48II in Physcomitrella patens results in freezing sensitivity after cold acclimation. Sci China Life Sci, 55(2):150-7

40. Xiao L, Wang H, Wan P, Kuang T, He Y* (2011). Genome-wide transcriptome analysis of gametophyte development in Physcomitrella patens. BMC Plant Biology, 11: 177 http://www.biomedcentral.com/1471-2229/11/177

41. Wang X, Kuang T, He Y* (2010). Conservation between higher plants and the moss Physcomitrella patens in response to phytohormone abscisic acid: analysis by proteomics approach. BMC Plant Biology, 10: 192 http://www.biomedcentral.com/1471-2229/10/192

42. Wang X, Yang P, Zhang X, Xu Y, Kuang T, Shen S*, He Y* (2009). Proteomic analysis of cold stress response in the moss Physcomitrella patens. Proteomics, 9: 4529-4538

43. Zhang M, Hu Y, Jia J, Li D, Zhang R, Gao H*, He Y* (2009). CDP1, a novel component of chloroplast division site positioning system in Arabidopsis. Cell Research, 19: 877-886

44. Zhang M, Hu Y, Jia J, Gao H*, He Y* (2009). A plant MinD homologue rescues Escherichia coli HL1 mutant (Delta MinDE) in the absence of MinE. BMC Microbiology, 9: 101 doi:10.1186/1471-2180-9-101

45. Wang XQ, Yang PF, Liu Z, Liu WZ, Hu Y, Chen H, Kuang TY, Pei ZM, Shen SH, He YK* (2009). Exploring the mechanism of Physcomitrella patens desiccation tolerance through a proteomic strategy. Plant Physiology, 149: 1739-1750

46. Wang XQ, He YK* (2009). Negative effects of desiccation on the protein sorting and post-translational modification. Plant Signaling & Behavior, 4: 435-437

47. Xia JC, Zhao H, Liu WZ, Li LG*, He YK* (2009). Role of cytokinin and salicylic acid in plants growth at low temperatures. Plant Growth Regulation, 57: 211-221

48. Cui S, Hu J, Yang B, Shi L, Huang F, Tsai SN, Ngai SM, He Y, Zhang J* (2009). Proteomic characterization of Phragmites communis in ecotypes of swamp and desert dune. Proteomics, 9: 3950-3967

49. Xue SW, Yang P, He YK* (2008). Nitric oxide suppresses stomatal opening by inhibiting inward-rectifying K+ in channels in Arabidopsis guard cells. Chinese Science Bulletin, 53: 2156-2159

50. Hu Y, Chen ZW, Liu WZ, Zhou WW, He YK*(2008). Chloroplast division regulated by the circadian expression of FtsZ and Min genes in Chlamydomonas reinhardtii. European Journal of Phycology, 43: 207-215

51. Wang X, Yang P, Gao Q, Liu X, Kuang T, Shen S*, He Y* (2008). Proteomic analysis of the response to high-salinity stress in Physcomitrella patens. Planta, 288: 167-177

52. Wang XQ, Liu Z, He YK* (2008). Responses and tolerance to salt stress in bryophytes. Plant Signaling & Behavior, 3(8): 516-518

53. Liu C, Zhang Y, Cao D, He Y, Kuang T, and Yang C* (2008). Structural and functional analysis of the anti-parallel strands in the lumenal loop of the major light-harvesting chlorophyll a/b complex of photosystem II (LHCIIb) by site-directed mutagenesis. J Boil Chem, 283(1): 487-495

54. Sun MM, Li LH, Xie H, Ma RC*, He YK* (2007). Differentially Expressed Genes under cold acclimation in Physcomitrella patens. J of Biochemi and Mol Bio, 40(6): 986-1001

55. Liu N, Zhong NQ, Wang GL, Li LJ, Liu XL, He YK*, Xia GX* (2007). Cloning and functional characterization of PpDBF1 gene encoding a DRE-binding transcription factor from Physcomitrella patens. Planta, 226(4): 827-838

56. Liu WZ, Hu Y, Zhang RJ, Zhou WW, Zhu JY, Liu XL, He YK*(2007). Transfer of a eubacteria-type cell division site-determining factor CrMinD gene to the nucleus from the chloroplast genome in Chlamydomonas reinhardtii. Chinese Bulletin of Science, 52: 2514-2521

57. Zhu J, Liu W, Zhou W, Hu Y, He Y (2007). A Nucleus-encoded topological specificity factor PpMinE in Physcomitrella patens has conserved function similar to its chloroplast-encoded ancestor. J Genet Genomics, 34(3): 229-38

58. Li LH, Wang XP & He YK*(2005). An efficient protocol for plant regeneration from protoplasts of the Moss Atrichum ndulatum P. Beauv in vitro. Plant Cell, Organ and Tissue Culture, 82: 281-288

59. He Y, Tang RH, Hao Y, Stevens RD, Cook CW, Ahn SM, Jing L, Yang Z, Chen L, Guo F, Fiorani F, Jackson RB, Crawford NM, Pei ZM* (2004). Nitric oxide represses the Arabidopsis floral transition. Science, 305: 1968-1971

60. Wang D, Kong D, Wang Y, Hu Y, He Y, Sun J* (2003). Isolation of two plastid division ftsZ genes from Chlamydomonas reinhardtii and its evolutionary implication for the role of FtsZ in plastid division. J Exp Bot, 54(384):1115-6

61. He Y, Li J* (2001). Differential expression of triplicate phosphoribosylanthranilate isomerase isogenes in the tryptophan biosynthetic pathway of Arabidopsis thaliana. Planta, 212(5-6): 641-7

62. Mou Z, He Y, Dai Y, Liu X, Li J* (2000). Deficiency in fatty acid synthase leads to premature cell death and dramatic alterations in plant morphology. Plant Cell, 12(3): 405-18

63. He Y, Liu X, Li J* (1999). Expression of Arabidopsis tryptophan biosynthetic pathway genes: effect of the 5' coding region of phosphoribosylanthranilate isomerase gene. Sci China C Life Sci, 42(3): 274-80

64. He Y, Zhu C, He M, Hao S (1996). Protoplast culture and plant regeneration of Pinellia ternate. Plant Cell Rep, 16(1-2): 92-6

65. He YK, Liu G, Lu TG and Sun JS (1994). STEM APEX CULTURE AND QUALITY IMPROVEMENT OF TUBERCLES OF PINELLIA TERNATA. Acta Botanica Sinica, 36 (1): 39-44

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