报告题目：Genetic and genomic characterization of hybrid between Caenorhabditis species

报告人：ZHONGYING  ZHAO

时间：2018年11月1日，下午2:00

地点：理科楼430

报告摘要：Systematic characterization of ?ybrid incompatibility (HI) between related species remains the key to understanding speciation. The genetic basis of HI has been intensively studied in Drosophila species and some plant species, but remains largely unknown in other species, including nematodes. This is mainly due to the lack of a sister species with which C. elegans, a nematode model organism, can mate and produce viable progeny. The recent discovery of a C. briggsae sister species, C. nigoni, has opened up the possibility for dissecting the genetic and molecular bases of HI between nematode species. In this talk, I will discuss our recent work on empowering the sister-species pair as a novel model for speciation genetics as well as the novel insights derived from study of the model using a combination of genetics, genomic and systems biology approaches.

报告人介绍：

PREVIOUS ACADEMIC POSITIONS
1. 1997/10 – 1998/04, Visiting scholar, National Key Laboratory of Medical Molecular Biology, Peking Union Medical College (PUMC), Beijing, China.
2. 1996/07 – 2000/04, Research Assistant, Division of Biochemistry, National Institute of Sports Science, Beijing, China.
3. 2010/10 – 2015/08, Assistant professor, Department of Biology, Hong Kong Baptist University.
4. 2015/09 – 2018/08, Associate professor, Department of Biology, Hong Kong Baptist University
PRESENT ACADEMIC POSITION
2018/09 - present, Professor, Department of Biology, Hong Kong Baptist University

PUBLICATIONS
Five most representative publications in recent 3 years
1. Ren X, Li R, Wei X, Bi Y, Ho VW, Ding Qiu, Zhang Z, Hsieh C, Young A, Zeng J, Liu X, Zhao Z*. Genomic bases of recombination suppression in the hybrid between hermaphroditic Caenorhabditis briggsae and gonochoristic C. nigoni. Nucleic Acids Res. 2018 Feb 16;46(3):1295-1307.
2. Chen L, Ho VW, Wong MK, Huang X, Chan L, Ng HC, Ren X, Yan H & Zhao Z*. Automated inference of signaling interactions at cellular resolution for every cell cycle of embryogenesis. Genetics (highlighted). 2018 May;209(1):37-49. doi: 10.1534/genetics.118.300820.
3. Li R, Ren X, Bi Y, Ho VW, Hsieh CL, Young A, Zhang Z, Lin T, Zhao Y, Miao L, Sarkies P*, Zhao Z*. Specific Downregulation of Spermatogenesis Genes Targeted by 22G RNAs in Hybrid Sterile Males Associated with an X-Chromosome Introgression. Genome Research. 2016, 26(9):1219-32
4. Ho VW, Wong MK, An X, Guan D, Shao J, Ng HC, Ren X, He K, Liao J, Ang Y, Chen L, Huang X, Yan B, Xia Y, Chan LL, Chow KL, Yan H, Zhao Z*. Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry. Molecular Systems Biology. 2015, 11(6):814
5. Yu Bi, Xiaoliang Ren, Cheung Yan, Jiaofang Shao, Dongying Xie and Zhongying Zhao*. Genome-Wide Introgression Revealed Pervasive Hybrid Incompatibilities (HI) between Caenorhabditis species. PLoS Genetics. 2015, 11(2):e1004993. Faculty of 1000 recommended.
* Corresponding author